A drama that deals with the brain and neurosurgeons. Lee Kang Hoon (Shin Ha Kyun) is a talented neurosurgeon who graduated from a top medical school and works at the top hospital in Korea, Chunha University Hospital. He has ambitions to become the director at Chunha and would go to great lengths to achieve this. He is obsessed with success, which is probably both his greatest flaw and strength, since it makes him steely and fierce. He finds a hated enemy, a rival and a teacher in Professor Kim Sang Chul (Jung Jin Young), a world famous neurologist whose friendly demeanor and kindness with his patients acts as a stark contrast to Lee Kang Hoon's cold and unforgiving attitude. Yoon Ji Hye (Choi Jung Won) is a third-year resident in the neurosurgery department who is well-liked for her warm bedside manner. She is initially a thorn in Kang Hoon's side with her criticisms of his behaviour, but later becomes his staunchest supporter. Seo Joon Suk (Jo Dong Hyuk) is Kang Hoon's classmate and rival in both love and career.